Oxytocin does not directly alter cardiac repolarization in rabbit or human cardiac myocytes
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منابع مشابه
Oxytocin does not directly alter cardiac repolarization in rabbit or human cardiac myocytes
Oxytocin, a nine amino acid peptide, is highly conserved in placental mammals, including humans. Oxytocin has a physiological role in parturition and parenteral administration of the synthetic peptide is used to induce labor and control postpartum hemorrhage. Endogenous levels of oxytocin before labor are ∼20 pg/mL, but pharmacological administration of the peptide can achieve levels of 110 pg/...
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or degraded and are replaced by actin and av-actinin-positive, myosin-negative structures that resemble myofibrils but lack thick filaments. Such structures are termed minute myofibrils. The length of the sarcomeres in these altered myofibrils is significantly less than length values obtained from freshly isolated heart cells or from contracting myocytes. A number of high density cultures devel...
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Phospholamban has been suggested to be a key regulator of cardiac sarcoplasmic reticulum (SR) Ca cycling and contractility and a potential therapeutic target in restoring the depressed Ca cycling in failing hearts. Our understanding of the function of phospholamban stems primarily from studies in genetically altered mouse models. To evaluate the significance of this protein in larger mammalian ...
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ژورنال
عنوان ژورنال: Pharmacology Research & Perspectives
سال: 2014
ISSN: 2052-1707
DOI: 10.1002/prp2.102